Biochem/physiol Actions
Tanshinone II A sulfonate is a water-soluble derivative of tanshinone II A that exhibits anti-inflammatory properties in rodent models of hepatitis and sepsis. Tanshinone II A sulfonate targets Ca2+-activated potassium channels and carboxylesterase 2. Recent studies indicate that tanshinone II A sulfonate but not tanshinone II A acts as potent negative allosteric modulator of the human purinergic receptor P2X7.
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