PRALATREXATE

Code: SML2494-5MG D2-231

Biochem/physiol Actions

Pralatrexate is an antifolate that selectively enters cancer cells expressing reduced folate carrier type 1 (RFC-1). Pralatrexate potently inhibits DH...


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Biochem/physiol Actions

Pralatrexate is an antifolate that selectively enters cancer cells expressing reduced folate carrier type 1 (RFC-1). Pralatrexate potently inhibits DHFR (dihydrofolate reductase).

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyOGSBUKJUDHAQEA-WMCAAGNKSA-N
InChI1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1
SMILES stringO=C([C@@H](NC(C1=CC=C(C(CC(N=C23)=CN=C3N=C(N=C2N)N)CC#C)C=C1)=O)CCC(O)=O)O
solubilityDMSO: 2 mg/mL
storage temp.−20°C
Cas Number146464-95-1
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