TICAGRELOR

Code: SML2482-10MG D2-231

Biochem/physiol Actions

Ticagrelor is an antithrombotic antiplatelet drug that acts by direct and reversible competitive inhibition of the adensoine purinoceptor P2Y12 recept...


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Biochem/physiol Actions

Ticagrelor is an antithrombotic antiplatelet drug that acts by direct and reversible competitive inhibition of the adensoine purinoceptor P2Y12 receptor. It has clinical benefits in people affected with acute coronary syndrome. It might also play a beneficial role on endothelial function. Ticagrelor can prevent the uptake of adenosine by human erythrocytes and can promote the liberation of adenosine triphosphate (ATP) from human erythrocytes.

General description

Ticagrelor (AZD6140) is a cyclopentyl-triazolopyrimidine.

assay≥98% (HPLC)
colorwhite to beige
formpowder
Gene Informationhuman ... P2RY12(64805)
InChI keyOEKWJQXRCDYSHL-FNOIDJSQSA-N
InChI1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1
optical activity[α]/D -55 to -65°, c = 0.2 in methanol
SMILES stringCCCSC1=NC(N[C@@]2([H])[C@@](C3=CC=C(F)C(F)=C3)([H])C2)=C4C(N([C@@]5([H])[C@H](O)[C@H](O)[C@@H](OCCO)C5)N=N4)=N1
solubilityDMSO: 2 mg/mL, clear
storage temp.−20°C
Cas Number274693-27-5
This product has met the following criteria to qualify for the following awards:



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