MEPB

Code: SML2455-25MG D2-231

Biochem/physiol Actions

MEPB is a modulator of the activation function-2 (AF-2) of the androgen receptor (AR), increasing AR co-repressor binding. MEPB specifically binds the...


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€301.30 25MG
€370.60 inc. VAT
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Biochem/physiol Actions

MEPB is a modulator of the activation function-2 (AF-2) of the androgen receptor (AR), increasing AR co-repressor binding. MEPB specifically binds the BF3 pocket of the androgen receptor where it modulates binding of co-regulators to the AF2 domain. MEPB was found to rescue degeneration in a mouse model of spinal bulbar muscular atrophy, a motor neuron disease caused by toxic gain of function of the androgen receptor.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringCC(C=C1)=CC=C1OCCN2C(SCCOC3=CC=CC=C3)=NC4=CC=CC=C42
solubilityDMSO: 2 mg/mL, clear
storage temp.−20°C
Cas Number331948-99-3
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