GSK690

Code: SML2419-5MG D2-231

Biochem/physiol Actions

GSK690 (GSK354) is a cell-permeable pyrrolidinylmethoxypyridine-based compound that inhibits lysine-specific demethylase 1 (LSD1; KDM1A) in a potent a...


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€68.00 5MG
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Biochem/physiol Actions

GSK690 (GSK354) is a cell-permeable pyrrolidinylmethoxypyridine-based compound that inhibits lysine-specific demethylase 1 (LSD1; KDM1A) in a potent and reversible manner (IC50= 90 nM) without affecting MAO-A activity (IC50>200 μM). GSK690 is shown to induce the expressions of CD86 (EC50= 1.4 μM in THP1 cells) and LY96 (EC50= 423 nM in MV4-11 cells), and prevent adipogenesis in murine preadipocyte cultures.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringN#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
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