ANDRASTIN A

Code: SML2385-1MG D2-231

Biochem/physiol Actions

Farnesyltransferase inhibitor with anticancer activity; mycotoxin

Andrastin A is a meroterpenoid protein farnesyltransferase inhibitor with anti...


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Biochem/physiol Actions

Farnesyltransferase inhibitor with anticancer activity; mycotoxin

Andrastin A is a meroterpenoid protein farnesyltransferase inhibitor with anticancer activity. It has been shown to inhibit the farnesyltransferase activity of the oncogenic Ras proteins and inhibit the efflux of anticancer drugs from multidrug-resistant cancer cells.

assay≥95% (HPLC)
colorwhite to beige
formpowder
InChI keyGRBXNADBNJGZRK-BCMOVVIDSA-N
InChI1S/C28H38O7/c1-15-13-19-25(6,28(23(33)34-8)22(32)16(2)21(31)26(15,28)7)11-9-18-24(4,5)20(35-17(3)30)10-12-27(18,19)14-29/h13-14,16,18-20H,9-12H2,1-8H3/t16?,18?,19-,20?,25?,26+,27+,28?/m0/s1
storage temp.−20°C
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