RU.521

Code: SML2347-5MG D2-231

Biochem/physiol Actions

RU.521 (RU320521) is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that suppresses the chronically elevated levels of type I inte...


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€149.07 5MG
€183.36 inc. VAT

Biochem/physiol Actions

RU.521 (RU320521) is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that suppresses the chronically elevated levels of type I interferon in primary macrophages from Trex1 null mice. Ru.521 binds to the CGAS catalytic pocket and inhibits dsDNA-induced cGAS-mediated interferon upregulation.

RU.521 helps to understand the biological functions of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP) synthase. It can act as a molecular scaffold for developing future autoimmune therapies. RU.521 can also inhibit the inflammatory cytokine expression induced by Aspergillus fumigatus.

assay≥98% (HPLC)
colorwhite to beige
formpowder
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
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