GEA-69

Code: SML2267-5MG D2-231

Biochem/physiol Actions

GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-surviva...


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€71.80 5MG
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Biochem/physiol Actions

GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites.

assay≥98% (HPLC)
coloroff-white to brown
formpowder
SMILES stringCC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43)=O
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
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