TAKINIB

Code: SML2216-5MG D2-231

Application

Takinib has been used as an inhibitor of transforming 28 growth factor - β-activated kinase -1 (TAK-1) in human leukemia monocyticTHP-1 cells. It may be used as a...


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€101.96 5MG
€125.41 inc. VAT
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Application

Takinib has been used as an inhibitor of transforming 28 growth factor - β-activated kinase -1 (TAK-1) in human leukemia monocyticTHP-1 cells. It may be used as a TAK1 inhibitor in Jurkat cells.

Biochem/physiol Actions

Takinib is a selective inhibitor of TAK1/MAP3K7 kinase, which is a member of the MAP3K family and a key regulator of cell death. It binds in the TAk1 ATPbinding pocket with an IC50 value of 9.5 nM. Takinib selectively induced apoptosis following TNF-α stimulation in rheumatoid arthritis and breast cancer.

General description

Takinib belongs to the aminobenzimidazole class of inhibitors.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringCCCN1C2=CC=CC=C2N/C1=NC(C3=CC(C(N)=O)=CC=C3)=O
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
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