RWJ 67657

Code: SML2212-5MG D2-231

Biochem/physiol Actions

RWJ 67657 is an orally active, potent and selective inhibitor of p38α and p38β MAP kinases. RWJ 67657 inhibits the release of TNF-α and...


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€86.90 5MG
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Biochem/physiol Actions

RWJ 67657 is an orally active, potent and selective inhibitor of p38α and p38β MAP kinases. RWJ 67657 inhibits the release of TNF-α and IL-1β from LPS induced blood mononuclear cells. It exhibits cardioprotective and anti-inflammatory activities in vivo.

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyQSUSKMBNZQHHPA-UHFFFAOYSA-N
InChI1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3,7-8,11-18,32H,5-6,9,19-20H2
SMILES stringOCCC#CC1=NC(C2=CC=C(F)C=C2)=C(C3=CC=NC=C3)N1CCCC4=CC=CC=C4
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
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