BRD6989

Code: SML2208-5MG D2-231

Biochem/physiol Actions

BRD6989 is an inhibitor of cyclin-dependent kinase 8 (CDK8) that upregulates production of interleukin-10 (IL-10). BRD6989 was shown to bind cyclin C&...


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€93.20 5MG
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Biochem/physiol Actions

BRD6989 is an inhibitor of cyclin-dependent kinase 8 (CDK8) that upregulates production of interleukin-10 (IL-10). BRD6989 was shown to bind cyclin C–CDK8 complex selectively with an IC50 value ~200 nM and to inhibit the kinase activity of recombinant cyclin C–CDK8 or cyclin C–CDK19 complexes with IC50 values ~500 nM and >30 µM, respectively. It enhanced the production interleukin-10 (IL-10) enhances IL-10 production in activated human and murine macrophages and dendritic cells with an EC50 value ~1 µM.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringNC1=NC(CCC(C)C2)=C2C(C3=CN=CC=C3)=C1C#N
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
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