A-485

Code: SML2192-25MG D2-231

Biochem/physiol Actions

A-485 is a potent and selective catalytic inhibitor of the p300 and CREB-binding protein (CBP) histone acetyltransferases (HATs) with an IC50

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Biochem/physiol Actions

A-485 is a potent and selective catalytic inhibitor of the p300 and CREB-binding protein (CBP) histone acetyltransferases (HATs) with an IC50 value of 60 nM. A-485 was most active against haematological malignancies including most multiple myeloma cell lines as well as androgen receptor-positive prostate cancer. It was also shown to inhibit the proliferation of castration-resistant prostate cancer cells and in vivo tumour growth in SCID mice.

assay≥98% (HPLC)
colorwhite to beige
formpowder
optical activity[α]/D +40 to +50°, c = 0.5 in methanol
Quality Level100
SMILES stringCNC(NC1=CC=C2C(CC[C@]23C(N(CC(N(CC4=CC=C(F)C=C4)[C@@H](C)C(F)(F)F)=O)C(O3)=O)=O)=C1)=O
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number1889279-16-6
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