POLOPPIN

Code: SML2186-5MG D2-231

Biochem/physiol Actions

Poloppin is a cell penetrant and potent inhibitor of mitotic Polo-like kinases (PLKs) that binds to the Polo-box domain (PBD) and prevents PLKs intera...


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€93.20 5MG
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Biochem/physiol Actions

Poloppin is a cell penetrant and potent inhibitor of mitotic Polo-like kinases (PLKs) that binds to the Polo-box domain (PBD) and prevents PLKs interaction with pSer/pThr phosphopeptide substrates. Poloppin induces mitotic arrest and apoptosis in cancer cells expressing mutant KRAS in 2D and organoid cultures. It also sensitizes mutant KRAS-expressing cancer cells to Crizotinib.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringOC(CCC1=CC=C(C2=CC=C(Br)C=C2)N1C3=CC=CC=C3C(F)(F)F)=O
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number216657-60-7
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