R-568 HYDROCHLORIDE

Code: SML2160-25MG D2-231

Biochem/physiol Actions

R-568 is a positive allosteric modulator of the calcium-sensing receptor (CaSR), increasing the sensitivity to activation by extracellular Ca2+

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€454.50 25MG
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Biochem/physiol Actions

R-568 is a positive allosteric modulator of the calcium-sensing receptor (CaSR), increasing the sensitivity to activation by extracellular Ca2+. In rats, orally administered R-568 decreases plasma levels of PTH and Ca2+ and, at higher doses, increases plasma levels of calcitonin.

assay≥95% (HPLC)
colorwhite to beige
formpowder
InChI keyYJXUXANREVNZLH-PFEQFJNWSA-N
InChI1S/C18H22ClNO.ClH/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19;/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3;1H/t14-;/m1./s1
optical activity[α]/D +35 to +40°, c = 0.5 in chloroform-d
SMILES stringC[C@@H](NCCCC1=C(C=CC=C1)Cl)C2=CC=CC(OC)=C2.Cl
solubilityDMSO: 2 mg/mL, clear (warmed)
storage conditiondesiccated
storage temp.2-8°C
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