ROFLUPRAM

Code: SML2106-5MG D2-231

Biochem/physiol Actions

Roflupram (FFPM) is a potent anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor that was found to suppress inflammasome activation in microglial c...


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€89.70 5MG
€110.33 inc. VAT

Biochem/physiol Actions

Roflupram (FFPM) is a potent anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor that was found to suppress inflammasome activation in microglial cells by enhancing autophagy. In microglial BV-2 cells roflupram enhanced the level of microtubule-associated protein 1 light chain 3 II (LC3-II) and decreased the autophagy receptor ubiquitin-binding protein p62 (SQSTM1), enhancing autophagy, reducing the activation of inflammasome and suppressing the production of IL-1β. Roflupram (FFPM) was found to reverse learning and memory deficits in APP/PS1 transgenic mice.

assay≥98% (HPLC)
colorcolorless to light brown
formoil
SMILES stringO=C(CC(C)C)C1=CC=C(OC(F)F)C(OC2CCOC2)=C1
storage temp.2-8°C
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