SML2075-25MG Display Image

GIMERACIL

Code: SML2075-25MG D2-231

Biochem/physiol Actions

Gimeracil (5-chloro-2, 4-dihydroxypyridine) is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine an...


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€167.71 25MG

Biochem/physiol Actions

Gimeracil (5-chloro-2, 4-dihydroxypyridine) is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine and the chemotherapeutic drug 5-fluorouracil (5FU). Gimeracil is shown to exhibit cancer-radiosensitizing efficacy in cultures in vitro (1 mM) and in mice in vivo (2.5-25 mg/kg, p.o.) in a DPYD-dependent manner via partial suppression of DNA repair by homologous recombination (HR).

assay≥98% (HPLC)
colorwhite to brown
formpowder
InChI keyZPLQIPFOCGIIHV-UHFFFAOYSA-N
InChI1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)
solubilityDMSO: 2 mg/mL, clear
storage temp.−20°C
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SML2075-5MG
Unit:5MG
List Price: €68.63
Source:List Price
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