ZD0947

Code: SML2055-25MG D2-231

Biochem/physiol Actions

ZD0947 is potent ATP-sensitive K+ channels (KATP channels) opener. ZD0947 is an effective activator of smooth muscle-type KATP channels (SUR2B/Kir6.1 ...


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€425.47 25MG
€523.33 inc. VAT
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Biochem/physiol Actions

ZD0947 is potent ATP-sensitive K+ channels (KATP channels) opener. ZD0947 is an effective activator of smooth muscle-type KATP channels (SUR2B/Kir6.1 and SUR2B/Kir6.2) but is a partial antagonist of pancreatic-type KATP channels (i.e. SUR1/Kir6.2) and cardiac-type KATP channels (i.e. SUR2A/Kir6.2). ZD0947 potently inhibits carbacho-induced contraction in the strips of human detrusor.

assay≥98% (HPLC)
colorwhite to beige
formpowder
optical activity[α]/D -625 to -575°, c = 0.5 in methanol
SMILES stringO=C1C2=C(NC(C(F)(F)F)=C[C@H]2C3=CC(C#N)=CC=C3)CCC1
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
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