S3226

Code: SML1996-5MG D2-231

Biochem/physiol Actions

S3226 is a potent and selective NHE3 (NHE-3) inhibitor (IC50 = 20 nM/human NHE3, 3.6 µM/human NHE1, 80 µM/rabbit NHE2) for studying NHE3 phy...


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€131.47 5MG
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Biochem/physiol Actions

S3226 is a potent and selective NHE3 (NHE-3) inhibitor (IC50 = 20 nM/human NHE3, 3.6 µM/human NHE1, 80 µM/rabbit NHE2) for studying NHE3 physiological as well as pathophysiological roles in kidney and gastrointestinal disorders in vitro and in animal models in vivo.

S3226 is also known as {3-[2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methyl-phenyl]-N-isopropylidene-2-methyl-acrylamide dihydro-chloride}. S3226 is used to explore the physiological and pathophysiological functions of sodium-hydrogen exchanger 3 (NHE3) in animal models. It is a bismethacryloyl guanidine derivative.

assay≥98% (HPLC)
colorwhite to beige
formpowder
shipped inambient
SMILES stringO=C(N=C(N)N)C(C)=CC1=CC(C)=CC=C1C=C(C)C(NC(N)=N)=O.[H]Cl.[H]Cl
solubilityH2O: 2 mg/mL, clear
storage temp.2-8°C
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