UCB35625

Code: SML1975-5MG D2-231

Biochem/physiol Actions

UCB35625 is a high affinity antagonist for CCR1 and CCR3 receptors. Also both UCB35625 and its enantiomer J113863 exhibit low binding affinity toward ...


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Biochem/physiol Actions

UCB35625 is a high affinity antagonist for CCR1 and CCR3 receptors. Also both UCB35625 and its enantiomer J113863 exhibit low binding affinity toward CCR2 and CCR5 where they activate three Gi and two G0 protein isoforms. UCB35625 does not activate G12 protein isoform. J113863 binding to CCR2 and CCR5 induce the recruitment of b-arrestin 2 whereas UCB35625 did not. J113863 and UCB35625 are biased ligands for the chemokine receptors CCR2 and CCR5.

assay>97% (HPLC)
colorwhite to beige
formpowder
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number202796-42-7
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