Application

S1QEL1.1 has been used as a reverse electron transport (RET)-induced mitochondrial (mito) reactive oxygen species (ROS) suppressor: to investigate the role of mitochondrial-derived superoxide in triggering ferroptosis to study the mechanism involved in the regulation of anti-fungal responses of macrophages against Aspergillus infection in combination with mito-antioxidant to study their influence on mitochondria-derived H₂O₂ in cancer cells to determine the effect of oxidative stress depletion on myoblast differentiation

Biochem/physiol Actions

Suppressors of the site IQ electron leak (S1QEL)1.1 reduces cytokine secretion and fungicidal activity of macrophages infected with swollen A. fumigatus conidia by suppressing reverse electron transport (RET)-induced mitochondrial reactive oxygen species (ROS).

S1QEL1.1 is a suppressor of mitochondrial respiratory complex I site IQ electron leak, suppressing superoxide and/or H₂O₂ production without altering oxidative phosphorylation. S1QEL1.1 had an IC50 values of 70 nM against superoxide-H₂O₂ production from site IQ. It decreased caspase activation in a in a cardiomyocyte cell model of ER stress and decreased ischemia-reperfusion injury in the Langendorff-perfused mouse heart model.