MK204

Code: SML1890-25MG D2-231

Biochem/physiol Actions

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10). AKR1B10 is induced in several cancer types, in particul...


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€570.66 25MG
Discontinued
€701.91 inc. VAT

Biochem/physiol Actions

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10). AKR1B10 is induced in several cancer types, in particular, hepatocellular carcinoma, and may be involved with drug resistance. MK204 appears to target a distinct AKR1B10 inner specificity pocket not present in the closely related aldose reductase. MK204 had an IC50 value of 80 nM compared to an IC50 value of 21.7 µM for aldose reductase.

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
SMILES stringO=C(C1=C(OCC(O)=O)C=C(C=C1)Cl)NCC(C(Br)=C(C(Br)=C2Br)Br)=C2Br
solubilityDMSO: 3 mg/mL, clear (warmed)
storage temp.2-8°C
Cas Number1959605-73-2
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