MITOTANE

Code: SML1885-100MG D2-231

Biochem/physiol Actions

Mitotane is a selective inhibitor of sterol-Oacyl-transferase 1 (SOAT1), also known as ACAT1, (acyl-coenzyme A cholesterol acyltransferase). Mitotane ...


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€62.80 100MG
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Biochem/physiol Actions

Mitotane is a selective inhibitor of sterol-Oacyl-transferase 1 (SOAT1), also known as ACAT1, (acyl-coenzyme A cholesterol acyltransferase). Mitotane inhibition of SOAT1 in adrenocortical carcinoma cells decreased the formation of cholesteryl esters, which increased free cholesterol levels and caused endoplasmic reticulum (ER) stress, the unfolded protein response, and eventually apoptosis.

Packaging

100 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyJWBOIMRXGHLCPP-UHFFFAOYSA-N
InChI1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
Quality Level100
SMILES stringClC1=C(C(C(Cl)Cl)C2=CC=C(Cl)C=C2)C=CC=C1
solubilityDMSO: 20 mg/mL, clear
storage temp.2-8°C
Cas Number53-19-0
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