AR231453

Code: SML1883-5MG D2-231

Biochem/physiol Actions

AR231453 is a 5-nitropyrimidine derivative that acts as a highly potent and selective GRP119 agonist (EC50/GPR119 species = 0.4 nM/monkey, 1.6 nM/dog,...


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€127.40 5MG
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Biochem/physiol Actions

AR231453 is a 5-nitropyrimidine derivative that acts as a highly potent and selective GRP119 agonist (EC50/GPR119 species = 0.4 nM/monkey, 1.6 nM/dog, 4.7 nM/hamster, 3.5 nM/human, 12 nM/mouse, 4 nM/rat in cell-based assays), exhibiting no off-target activity toward 216 receptors, enzymes, and orphan GPCRs. AR231453 improves glucose tolerance in mice (3 mg/kg i.p. or 20 mg/kg, p.o.) and rats (3 mg/kg i.p.), while no in vivo efficacy is observed among GPR119-deficient mice.

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
SMILES stringCC(C)C1=NOC(C(CC2)CCN2C(N=CN=C3NC4=CC=C(C=C4F)S(=O)(C)=O)=C3[N+]([O-])=O)=N1
solubilityDMSO: 20 mg/mL, clear
storage conditiondesiccated
storage temp.−20°C
Cas Number733750-99-7
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