BRUSATOL

Code: SML1868-25MG D2-231

Application

Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.


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€512.50 25MG
€630.38 inc. VAT
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Application

Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.

Biochem/physiol Actions

Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.

Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 ﹤1 µM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. ﹤50 nM in A549 cells), including NRF2.

Packaging

5, 25 mg in glass bottle

assay≥95% (HPLC)
biological source(Brucia javanica)
colorwhite to beige
formpowder
InChI keyZZZYHIMVKOHVIH-VILODJCFSA-N
InChI1S/C26H32O11/c1-10(2)6-15(28)37-18-20-25-9-35-26(20,23(33)34-5)21(31)17(30)19(25)24(4)8-13(27)16(29)11(3)12(24)7-14(25)36-22(18)32/h6,12,14,17-21,29-31H,7-9H2,1-5H3/t12-,14+,17+,18+,19+,20+,21-,24-,25+,26-/m0/s1
optical activity[α]/D +35 to +44°, c = 0.5 in acetone
Quality Level100
SMILES stringCC1=C(O)C(C[C@@]2(C)[C@@]1([H])C[C@]3([H])[C@]45[C@]2([H])[C@@H](O)[C@H](O)[C@](OC5)(C(OC)=O)[C@]4([H])[C@@H](OC(C=C(C)C)=O)C(O3)=O)=O
solubilityDMSO: 5 mg/mL, clear (warmed)
storage conditiondesiccated
storage temp.−20°C
Cas Number14907-98-3
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