RI(DL)-2

Code: SML1851-25MG D2-231

Biochem/physiol Actions

RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC50 = 11.1 µM) ...


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€369.60 25MG
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Biochem/physiol Actions

RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC50 = 11.1 µM) without affecting its ssDNA-binding activity (IC50 >100 µM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC50 = 3.0 µM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
color, light orange to dark red
formpowder
Quality Level100
SMILES stringCCNC1=CC=C(C2=NC3=C(N4C2=CC=C4)C=CC=C3)C=C1.FC(F)(C(O)=O)F
solubilityDMSO: 20 mg/mL, clear
storage temp.2-8°C
Cas Number1902146-75-1
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