PFM39

Code: SML1839-25MG D2-231

Biochem/physiol Actions

PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity. PFM39 targets MRE11 in a fashion...


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€681.25 25MG
Discontinued
€837.94 inc. VAT

Biochem/physiol Actions

PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity. PFM39 targets MRE11 in a fashion similar to Mirin, but distinct from that of PFM01 to allow a blockage of dsDNA phosphate backbone rotation and selective inhibition against MRE11 exo-, but not endo-, nuclease activity. FM39 potently impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR).

assay≥98% (HPLC)
coloryellow to orange
formpowder
Quality Level100
SMILES stringNC1=CC=C(/C=C2SC(NC2=O)=N)C=C1
solubilityDMSO: 15 mg/mL, clear
storage temp.2-8°C
Cas Number1310744-67-2
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