Biochem/physiol Actions

Displurigen is a cell-permeable, phenylthiochromen-4-one derived compound that disrupts the pluripotency of human embryonic stem cells by targeting HSPA8/HSC70 and affects its binding to Oct4. Inhibits ATPase activity of HSP70 (IC50 = 225 µM). Displurigen has shown to diminish the mRNA levels of Oct4 and Nanog within 24 hours of treatment and causes a complete annihilation of OCT4+  and NANOG+  bearing cells within 4 days of treatment (~ 10 µM). It does not induce apoptosis and has no significant effect on cell cycle progression.

Packaging

5, 25 mg in glass bottle