SPP86

Code: SML1435-5MG D2-231

Biochem/physiol Actions

SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC50 value of 8 nM and with some inhibitory activity at EphA1, FG...


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€112.84 5MG
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Biochem/physiol Actions

SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC50 value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or BCR-ABL. SPP86 inhibited RET-mediated activation of the PI3K/Akt and MAPK pathways at doses of 0.1- 1 µM in a cell line expressing oncogenic RET and inhibited RET-induced ERα phosphorylation and proliferation in MCF7 cells with an IC50 value of 1.0 µM, similar to tamoxifen.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyJQOIRTDBHMDWMT-UHFFFAOYSA-N
InChI1S/C16H15N5/c1-11(2)21-16-14(15(17)18-10-19-16)13(20-21)9-8-12-6-4-3-5-7-12/h3-7,10-11H,1-2H3,(H2,17,18,19)
Quality Level100
SMILES stringNC1=NC=NC2=C1C(C#CC3=CC=CC=C3)=NN2C(C)C
solubilityDMSO: 10 mg/mL, clear
storage temp.2-8°C
Cas Number1357349-91-7
This product has met the following criteria to qualify for the following awards:



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