Name: PIK-294
Brand: SIGMA-ALDRICH
SKU: SML1381-5MG
Price: 155.30 EUR
Availability: InStock

Application

PIK-294 has been used as PI3K inhibitor in drug combination studies and their synergy quantification using the Chou-Talalay method.

Biochem/physiol Actions

PIK-294 is a highly selective inihibitor of the phosphoinositide 3-kinase (PI3K) p110δ with an IC₅₀ value of 10 nM compared to IC₅₀ values of 10 µM, 490 nM and 160 nM for PI3Kα/β/γ, respectively. PIK-294 has been used to help distinguish the unique roles of the various PI3-K isoforms. For example, in a study of CXCL8-induced neutrophil migration, PIK-294 inhibited both chemokinetic and chemotactic CXCL8-induced migration whereas PI3Kγ inhibitor AS-605240 markedly reduced CXCL8 induced chemokinetic migration but had no effect on CXCL8 induced chemotactic migration.

Packaging

5, 25 mg in glass bottle

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI key	WFSLJOPRIJSOJR-UHFFFAOYSA-N
InChI	1S/C28H23N7O2/c1-16-7-3-4-12-21(16)35-22(32-20-11-5-8-17(2)23(20)28(35)37)14-34-27-24(26(29)30-15-31-27)25(33-34)18-9-6-10-19(36)13-18/h3-13,15,36H,14H2,1-2H3,(H2,29,30,31)
Quality Level	100
SMILES string	NC1=C2C(N(CC(N3C4=C(C)C=CC=C4)=NC5=C(C(C)=CC=C5)C3=O)N=C2C6=CC(O)=CC=C6)=NC=N1
solubility	H₂O: 10 mg/mL, clear, DMSO: 5 mg/mL, clear (warmed)
storage temp.	−20°C

Safety Data Sheet for SML1381-5MG

Cas Number	900185-02-6
Hazard Class	6.1
Un Number	2811
Pack Group	III

This product has met the following criteria to qualify for the following awards:

PIK-294

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