INGELOL-3-ANGELATE

Code: SML1318-1MG D2-231

Biochem/physiol Actions

Ingenol 3-Angelate is a diterpenoid ester isolated from Euphorbia peplus that induces rapid cell death with keratinocytes and some cancer cel...


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€199.80 1MG
€245.75 inc. VAT
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Biochem/physiol Actions

Ingenol 3-Angelate is a diterpenoid ester isolated from Euphorbia peplus that induces rapid cell death with keratinocytes and some cancer cell lines. Ingenol 3-Angelate is a protein kinase C activator that displays potent antileukemic activity. Ingenol 3-Angelate (ingenol mebutate) is used for treatment of actinic keratosis.

Ingenol-3-angelate, is a phorbol ester-like compound or a diacylglycerol analog that is used in the treatment of several disorders like skin cancer. It is also known as PEP005. Ingenol-3-angelate stimulates the initiation of the enzyme by providing PKCs (protein kinase C) to cellular membranes.

Packaging

1 mg in glass bottle

assay≥95% (HPLC)
biological sourcesemisynthetic
colorwhite to beige
formpowder
InChI keyVDJHFHXMUKFKET-WDUFCVPESA-N
InChI1S/C25H34O6/c1-7-12(2)22(29)31-21-13(3)10-24-14(4)8-17-18(23(17,5)6)16(20(24)28)9-15(11-26)19(27)25(21,24)30/h7,9-10,14,16-19,21,26-27,30H,8,11H2,1-6H3/b12-7-/t14-,16+,17-,18+,19-,21+,24+,25+/m1/s1
Quality Level100
SMILES stringO=C1[C@@]2(C=C(C)[C@@H]3OC(/C(C)=CC)=O)[C@]3(O)[C@H](O)C(CO)=C[C@@]1([H])[C@@](C4(C)C)([H])[C@@]4([H])C[C@H]2C
solubilityDMSO: 15 mg/mL, clear
storage temp.−20°C
Cas Number75567-37-2
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