SAG Dihydrochloride

Code: SML1314-1MG D2-231

Application

Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist:to study its effects on mouse hippocampal cellsto determine its e...


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€135.70 1MG
€166.91 inc. VAT
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Application

Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist:to study its effects on mouse hippocampal cellsto determine its effects on the mitochondrial network in zebrafish embryoto study its effects on murine embryonic fibroblasts

Biochem/physiol Actions

SAG is a potent and cell-permeable smoothened (Smo) agonist that activates Hedgehog pathway and counteracts Cyclopamine inhibition of Smo.

Packaging

1, 5 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formlyophilized solid
InChI keyVFSUUTYAEQOIMW-YHBQERECSA-N
InChI1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
Quality Level100
SMILES stringO=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4
solubilityH2O: 20 mg/mL, clear
storage conditiondesiccated
storage temp.−20°C
Cas Number912545-86-9
Hazard Class6.1
Un Number2811
Pack GroupIII
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