BMS 204352

Code: SML1313-5MG D2-231

Application

BMS 204352 has been used in drug administration.

Biochem/physiol Actions

BMS 204352 (MaxiPost [(3S)-(+)-(5-chloro-2-methoxyp...


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Your Price
€166.70 5MG
€205.04 inc. VAT

Application

BMS 204352 has been used in drug administration.

Biochem/physiol Actions

BMS 204352 (MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one)] is used to treat ischemic stroke. It also acts as an activator of KNCQ4 (KQT-like subfamily, member 4) and KCNQ5 (KQT-like subfamily, member 5) with equal potency.

BMS 204352 is a potassium channel modulator. Originally developed as a potent opener of large-conductance, calcium-activated (Maxi-K, KCa1.1, BK) potassium channels, BMS 204352 also acts as a positive modulator at Kv7 (KCNQ) channels.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Gene Informationhuman ... KCNMA1(3778), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479)
InChI keyULYONBAOIMCNEH-HNNXBMFYSA-N
InChI1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
Quality Level100
SMILES stringO=C1NC2=CC(C(F)(F)F)=CC=C2[C@@]1(C3=CC(Cl)=CC=C3OC)F
solubilityDMSO: 20 mg/mL, clear
storage temp.−20°C
Cas Number187523-35-9
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