Biochem/physiol Actions

Rubone has strong anticancer activity. Rubone and paclitaxel (PTX) combination therapy retarded cancer cell growth, migration and cancer stem-like cells (CSC) population growth.

Rubone is a miR34a modulator that specifically restores miR34a in hepatocellular carcinoma cells with wild-type or mutated p53. Rubone potently inhibits growth of hepatocellular carcinoma in a mouse xenograft model. Rubone does not effect the growth of nontumorigenic human hepatocytes.

Rubone is a miR34a modulator that specifically restores miR34a in hepatocellular carcinoma cells.

Packaging

5, 25 mg in glass bottle