ROSUVASTATIN CALCIUM

Code: SML1264-50MG D2-231

Application

Rosuvastatin calcium has been used to determine the effect of the treatment with SIM, rosuvastatin or PRA on cholesterol and HMGCR levels in HeLa cells and to eva...


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€533.20 50MG
€655.84 inc. VAT
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Application

Rosuvastatin calcium has been used to determine the effect of the treatment with SIM, rosuvastatin or PRA on cholesterol and HMGCR levels in HeLa cells and to evaluate the in vivo effects of statins on glucose homeostasis.

Biochem/physiol Actions

Rosuvastatin calcium is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin calcium is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

General description

Rosuvastatin calcium (ROS) has a molecular mass of 1001.14. ROS is a member of the "statins" group and is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.

Packaging

10, 50 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyLALFOYNTGMUKGG-BGRFNVSISA-L
InChI1S/2C22H28FN3O6S.Ca/c2*1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h2*5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;;+2/p-2/b2*10-9+;/t2*16-,17-;/m11./s1
optical activity[α]/D +12 to +18°, c = 1 in methanol: water (1:1)
Quality Level100
solubilityDMSO: 10 mg/mL, clear
storage conditiondesiccated
storage temp.2-8°C
Cas Number147098-20-2
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