EFINACONAZOLE

Code: SML1244-50MG D2-231

Application

Efinaconazole has been used as:a topical anti-onychomycosis drug to determine its effects on Trichophyton rubrum and Trichophyton interdigitalea...


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Your Price
€363.35 50MG
€446.92 inc. VAT

Application

Efinaconazole has been used as:a topical anti-onychomycosis drug to determine its effects on Trichophyton rubrum and Trichophyton interdigitaleas an anti-fungal agent to study its permeability into the nail lysatesas an anti-fungal agent to study its effects on Candida africana and Candida dubliniensis

Biochem/physiol Actions

Efinaconazole exhibits its activity against pathogens such as Trichophyton mentagrophytes, Trichophyton rubrum, and Candida albicans. It is active against Candida sp. that cause nail and skin candidiasis. Efinaconazole is also effective against Malassezia sp. that causes tinea versicolor.

Efinaconazole is a triazole antifungal drug approved clinically for the treatment of nail fungus (Onychomycosis). It inhibits sterol biosynthesis by inhibition of cytochrome P450 14α-demethylase, an enzyme in the sterol biosynthesis pathway that leads from lanosterol to ergosterol. Efinaconazole has better nail penetration, so is more effective than other topical agents and as effective as oral medication for nail fungus.

Packaging

10, 50 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
optical activity[α]/D -85 to -95°, c = 1 in chloroform
Quality Level100
solubilityDMSO: 20 mg/mL, clear
storage temp.−20°C
Cas Number164650-44-6
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