INDISULAM

Code: SML1225-5MG D2-231

Biochem/physiol Actions

Indisulam is synthetic sulfonamide compound. In vitro and in vivo studies point out that indisulam prevents retinoblastoma protein p...


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Your Price
€166.70 5MG
€205.04 inc. VAT

Biochem/physiol Actions

Indisulam is synthetic sulfonamide compound. In vitro and in vivo studies point out that indisulam prevents retinoblastoma protein phosphorylation. Also, it inhibits cyclins A and B1 activity. Indisulam is known to promote apoptosis. Indisulam is a potent inhibitor of cellular dehydrogenases and thus, is likely to interfere with metabolic pathways such as malate-aspartate shuttle, glycolysis and gluconeogenesis.

Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to pink
formpowder
InChI keySETFNECMODOHTO-UHFFFAOYSA-N
InChI1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
Quality Level100
SMILES stringClC1=CNC2=C1C=CC=C2NS(C3=CC=C(S(=O)(N)=O)C=C3)(=O)=O
solubilityDMSO: 20 mg/mL, clear
storage temp.−20°C
Cas Number165668-41-7
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