EZATIOSTAT

Code: SML1081-25MG D2-231

Application

Ezatiostat has been used as glutathione S-transferase P1 (GSTP1) inhibitor:to study its effects on peroxiredoxin 6 (PRDX6) inhibition in neonatal rat testicular g...


read more

Your Price
€566.30 25MG
€696.55 inc. VAT

Application

Ezatiostat has been used as glutathione S-transferase P1 (GSTP1) inhibitor:to study its effects on peroxiredoxin 6 (PRDX6) inhibition in neonatal rat testicular gonocytesfor the incubation of bronchial epithelial cells in proteolysis assayto study its effects on the cystine-glutamate antiporter xCT (SLC7A11) expression in tumor cells

Biochem/physiol Actions

Ezatiostat is an inhibitor of glutathione S-transferase P1-1 (GSTP1-1) with hematopoiesis-stimulating activity. After intracellular de-esterification, the active form of ezatiostat binds to and inhibits GST P1-1, leading to activation of Jun kinase (JNK), a key regulator of cellular growth and differentiation of blood precursor cells, thereby restoring JNK and MAPK pathway activities and promoting MAPK-mediated cellular proliferation and differentiation. Ezatiostat promotes the proliferation and maturation of hematopoietic precursor cells, granulocytes, monocytes, erythrocytes and platelets. Ezatiostat has recently been given orphan drug designation for it for the treatment of myelodysplastic syndrome.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
solubilityDMSO: 5 mg/mL, clear (warmed)
storage temp.2-8°C
Cas Number168682-53-9
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN


GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.