K145 HYDROCHLORIDE

Code: SML1003-25MG D2-231

Application

K145 hydrochloride has been used in the analysis of apoptosis.

Biochem/physiol Actions

K145 (3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl...


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Your Price
€388.20 25MG
€477.49 inc. VAT

Application

K145 hydrochloride has been used in the analysis of apoptosis.

Biochem/physiol Actions

K145 (3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is a selective inhibitor of sphingosine kinase-2 (SphK2) and an anticancer agent. K145 selectively inhibited SphK2 in a dose-dependent manner with an IC50 of 4.30 +/- 0.06 μM with no inhibition of SphK1 at concentrations up to 10 μM. K145 significantly suppressed the growth of U937 tumors in nude mice and the growth of JC tumor cells in BALB/c mice.

It has the ability to prevent leukemia cell growth in vitro.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

K145 hydrochloride (3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is an analog of sphingosine.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
solubilityDMSO: 20 mg/mL, clear
storage temp.2-8°C
Cas Number1449240-68-9
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