4(MU)8C

Code: SML0949-25MG D2-231

Biochem/physiol Actions

4µ8C is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. 4µ8C inhibits regulated IRE1-...


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Your Price
€504.20 25MG
€620.17 inc. VAT

Biochem/physiol Actions

4µ8C is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. 4µ8C inhibits regulated IRE1-dependent degradation (RIDD) and unconventional spicing of XBP1 mRNA in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.

4μ8C is a salicylaldehyde derivative and its inhibitory action targets the K907 lysine residue in RNase (ribonuclease) domain and affects IRE1α (endoplasmic reticulum to nucleus signaling 1) RNase activity. In vitro analysis proved that 4μ8C was able to inhibit the release of insulin at high glucose levels.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
solubilityDMSO: 5 mg/mL, clear (warmed)
storage temp.−20°C
Cas Number14003-96-4
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