Application

Aurora-A Inhibitor I has been used to study its effect on cell viability of human megakaryoblastic cell line (SET-2) and human erythroleukemia cell line (HEL) by methylthiazoletetrazolium (MTT) assay.

Biochem/physiol Actions

Aurora-A Inhibitor I, also known as TC‐S7010, stimulates G2/M cell cycle arrest and apoptosis in ARID1A −/− cells.

Aurora-A Inhibitor I is a potent inhibitor of Aurora kinase A with an IC₅₀ of 3.4 nM and 1000-fold selectivity for Aurora A over Aurora B (better than VX-680) and even higher for CDKs. Antiproliferative IC₅₀ values were in the vicinity of 1 µM against the human colorectal cancer cell line HCT116.

Packaging

5, 25 mg in glass bottle