MHY1485

Application

MHY1485 has been used:to study the effect of mammalian target of rapamycin mTOR signalling on in vitro O-GlcNAcylationto inhibit autophagyas a mTOR agonist to demonstrate that the O-linked N-acetylglucosamine transferase- RNA helicase p68 (OGT-DDX5) axis regulates colorectal cancer cell proliferation and metastasis

Biochem/physiol Actions

MHY1485 binds to the mammalian target of rapamycin (mTOR) and stimulates its action. MHY1485 has the ability to penetrate the cell. It prevents the ultraviolet-induced oxidative stress in keratinocytes and fibroblasts.

MHY1485 is mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

5, 25 mg in glass bottle