AMTB hydrate, >=98% (HPLC)

Code: SML0103-5MG D2-231

Application

AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murin...


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€131.50 5MG
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Application

AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murine T cells.

Biochem/physiol Actions

AMTB is a 2-benzyloxy-benzoic acid amide derivative, which also inhibits voltage-gated sodium channels (Nav) and their isoforms.

AMTB is a TRPM8-selective antagonist with no cross reactivity to TRPV1 or 4. The pIC50 of icilin activation of TRPM8 is 6.23 i.v. administration of AMTB reduced the frequency of rhythmic contractions in volume-loaded bladder and inhibited blood pressure and visceromotor reflex responses to bladder distention.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to tan
formpowder
InChI keyRTYVTAQFASBIDN-UHFFFAOYSA-N
InChI1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2
Quality Level100
SMILES stringO=C(C1=C(OCC2=C(C)C=CC=C2)C=CC=C1)N(CCCN)CC3=CC=CS3.Cl.O
solubilityDMSO: ≥10 mg/mL
storage conditiondesiccated
storage temp.2-8°C
Cas Number926023-82-7
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