DBeQ, >=98% (HPLC)

Code: SML0031-5MG D2-231

Application

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.

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€110.77 5MG
€136.25 inc. VAT

Application

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.

Biochem/physiol Actions

DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyQAIMUUJJAJBPCL-UHFFFAOYSA-N
InChI1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
Quality Level100
SMILES stringC(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4
solubilityDMSO: ≥20 mg/mL
storage temp.room temp
Cas Number177355-84-9
This product has met the following criteria to qualify for the following awards:



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