General description

5-Methoxy-L-tryptophan is a L-tryptophan metabolite that exhibits anti-inflammatory and tumor-suppressing activities. 5-Methoxy-L-tryptophan is synthesized by tryptophan hydroxylase (TPH) and hydroxyindole O-methyltransferase (HIOMT). Recent study indicates 5-methoxytryptophan as a biomarker of progression of chronic kidney disease (CKD). Its levels decrease during disease and treatment with 5-methoxytryptophan ameliorates kidney fibrosis n mice model of CKD. 5-Methoxytryptophan appears to inhibit I?B/NF-?B signaling and enhaces Keap1/Nrf2 signaling in mice model of unilateral ureteral obstruction. Literature often uses the name 5-Methoxytryptophan instead L-5-Methoxytryptophan.