D425 Med Human Medulloblastoma Cell Line

Cell Line Origin

Human, Cancer Cells

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Medulloblastoma is one of the most common malignant brain tumors in children, with the highest number of diagnoses occurring in patients between 6 and 8 years of age (1). Medulloblastomas are subdivided into four subtypes based on molecular genetic characteristics: WNT, sonic hedgehog (SHH), group 3 and group 4 (1). Of these, group 3 is characterized by amplification of the oncogene MYC, one of the most common gene alterations associated with medulloblastoma.The D425 Med human medulloblastoma cell line is one of the most highly cited cellular models for medulloblastoma and is classified as a subgroup 3, harboring MYC amplification as well as mutant P53 (2). The D425 Med medulloblastoma cell line was derived from tumor cells of 6-year old patient and grows as suspended or lightly-adherent cell clumps in culture. D425 Med medulloblastoma cells are positive for neurofilament proteins but negative for GFAP (3). ﹤bold>Source:﹤/bold>The D425 medulloblastoma cell line was derived from biopsy of a tumor from a 6-year-old male patient (2).Research Category:Cancer

Other Notes

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact [email protected].

Packaging

≥1X10⁶ cells/vial

Storage and Stability

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.