ANTI-STIM1 (C-TERMINAL)

Code: S6197-100UL D2-231

Application

Anti-STIM1 (C-terminal) antibody produced in rabbit has been used in:western blotimmunoprecipitationimmunofluorescenceimmunohistochemistry

Biochem/p...


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Your Price
€498.00 100UL
€612.54 inc. VAT

Application

Anti-STIM1 (C-terminal) antibody produced in rabbit has been used in:western blotimmunoprecipitationimmunofluorescenceimmunohistochemistry

Biochem/physiol Actions

Stromal interaction molecule 1 (STIM1) is required for the activation of store-operated Ca2+ influx. STIM1 undergoes rapid oligomerization and redistributes into discrete spots (punctae) that move towards and accumulate in the cell periphery, possibly to activate Orai1 that is located in the plasma membrane. Overexpression of STIM1 and Orai1 together markedly increases the calcium release-activated channels (CRAC) current (I-CRAC). Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex plays a major role in the activation of store-operated calcium (SOC) channel in response to internal Ca2+ store depletion.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Stromal interaction molecule 1 (STIM1) is a conserved single-pass transmembrane protein. STIM1 is expressed ubiquitously in a wide variety of human primary and transformed cell types. STIM1 localizes predominantly in the membrane of the endoplasmic reticulum (ER). It contains an N-terminal EF hand motif located in the ER lumen and appears to function as a sensor of ER Ca2+ levels.

Immunogen

synthetic peptide corresponding to amino acids 657-683 of human STIM1, conjugated to KLH via an N-terminal residue. The corresponding sequence is identical in rat, mouse, bovine, monkey, and dog.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
concentration~1 mg/mL
conjugateunconjugated
formbuffered aqueous solution
Gene Informationhuman ... STIM1(6786)mouse ... Stim1(20866)rat ... Stim1(117086)
mol wtantigen 90 kDa
Quality Level200
shipped indry ice
species reactivityrat, mouse, human
storage temp.−20°C
technique(s)western blot: 2-4 µg/mL using whole extract of mouse 3T3 cells., immunoprecipitation (IP): 2.5-5 µg using extracts of rat PC12 cells., indirect immunofluorescence: 2.5-5 µg/mL using human HeLa cells.
UniProt accession no.Q13586
This product has met the following criteria to qualify for the following awards:



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