ANTI-SIRT1 (C-TERMINAL)

Code: S5322-100UL D2-231

Application

Anti-Sirt1 (C-terminal) antibody has been used inimmunoblottingimmunoprecipitationimmunofluorescenceimmunohistochemistrywestern blotting

Biochem/phy...


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€411.00 100UL
€505.53 inc. VAT

Application

Anti-Sirt1 (C-terminal) antibody has been used inimmunoblottingimmunoprecipitationimmunofluorescenceimmunohistochemistrywestern blotting

Biochem/physiol Actions

Sirtuin-1 (SIRT1) is a NAD-dependent deacetylase which has been implicated in the regulation of several transcription factors, including p53, forkhead box protein O (FOXO), nuclear factor kappa-B (NFκB), myocyte-specific enhancer factor 2 (Mef2), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α).

SIRT1 (sirtuin 1) functions as a regulator of various metabolic pathways, and influences the pathophysiology of several metabolic diseases. It is a regulator of protein deacetylation, and is a candidate therapeutic target in non-alcoholic fatty liver disease (NAFLD), amyotrophic lateral sclerosis (ALS), kidney disease, and pulmonary disease. It also participates in tumorigenesis, and whether it functions as an oncogene or as a tumor suppressor depends upon the tumor type. In ancreatic ductal adenocarcinoma (PDAC) its elevated expression is linked with poor prognosis, and innon-small-cell lung cancer (NSCLC) it suppresses the expression of tumor suppressor p27. It is also thought to function as a suppressor of cardiovascular disorders, such as myocardial infarction, or neurodegenerative diseases, such as Alzheimer′s disease (AD) or Parkinson′s disorder (PD).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

SIRT1 (sirtuin 1) belongs to the silent information regulator (SIR) 2 family and is a class to HDAC (histone deacetylase). It is expressed in various tissues including brain, liver, pancreas, adipose tissue, and skeletal muscle. SIRT1 is also known as the longevity gene.

Sirtuin-1 (SIRT1) resides in the nucleus.

Immunogen

synthetic peptide corresponding to amino acids 723-736 of human SIRT1, conjugated to KLH via an N-terminal cysteine residue.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
concentration~1.0 mg/mL
conjugateunconjugated
formbuffered aqueous solution
Gene Informationhuman ... SIRT1(23411)mouse ... Sirt1(93759)rat ... Sirt1(309757)
mol wtantigen ~120 kDa
Quality Level200
shipped indry ice
species reactivityhuman
storage temp.−20°C
technique(s)immunoprecipitation (IP): 5-10 µg using extracts of Jurkat cells, western blot: 1-2 µg/mL using whole extracts of Jurkat cells, indirect immunofluorescence: 10-20 µg/mL using human U-2-OS cells
UniProt accession no.Q96EB6
This product has met the following criteria to qualify for the following awards:



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