SIS3, >=98% (HPLC), powder

Code: S0447-5MG D2-231

Application

Sugar insensitive 3 (SIS3) has been used as smad3inhibitor in various cells.

Biochem/physiol Actions

SIS3 is a novel specific inhibit...


 Read more

Your Price
€410.97 5MG
€505.49 inc. VAT
REQUEST

Application

Sugar insensitive 3 (SIS3) has been used as smad3inhibitor in various cells.

Biochem/physiol Actions

SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3

Sugar insensitive 3 (SIS3) promotes drug-induced apoptosis and hinders the function of adenosine triphosphate (ATP)-binding cassette (ABC) transporter (ABCB1) and ABCG2. It resensitizes ABCB1 and ABCG2 overexpressed in cancerous cells, which contributes to chemotherapeutics.

Packaging

5 mg in glass bottle

assay≥98% (HPLC)
coloryellow
formpowder
InChI keyCDKIEBFIMCSCBB-CALJPSDSSA-N
InChI1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
Quality Level100
SMILES stringCl.COc1cc2CCN(Cc2cc1OC)C(=O)C=Cc3c(-c4ccccc4)n(C)c5ncccc35
solubilityH2O: ﹤2 mg/mL, DMSO: >20 mg/mL
storage temp.2-8°C
Cas Number521984-48-5
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN
GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.