Features and Benefits
The azido-dPEG®4 contains an azide function on one end of a single molecular weight dPEG® spacer (17.7 Å) and a reactive group on the other end of the spacer. The dPEG® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. The acid function may be activated with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) or N,N′-dicyclohexylcarbodiimide (DCC) for conjugation to an amine. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.
Legal Information
dPEG is a registered trademark of Quanta BioDesign
Products Protected under U.S. Patents # 7,888,536 B2
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