Pamidronate disodium salt hydrate, >=95% (NMR), solid

Code: P2371-10MG D2-231

Biochem/physiol Actions

Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC50 = 200 nM).

Pamidronate disodiumhas the ability to block W...


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€188.50 10MG
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Biochem/physiol Actions

Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC50 = 200 nM).

Pamidronate disodiumhas the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

10, 100 mg in glass bottle

assay≥95% (NMR)
colorwhite
formsolid
InChI keyTVQNUQCYOOJTMK-UHFFFAOYSA-L
InChI1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2
mp300 °C
originatorNovartis
Quality Level100
SMILES stringO.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O
solubilityH2O: 28 mg/mL
storage temp.2-8°C
Cas Number57248-88-1
This product has met the following criteria to qualify for the following awards:



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